"Knucks" doesn't appear in standard card game references (Hoyle, Pagat, BGG, major rulebooks). It's likely a regional/family variant, a mishearing of another game, or a new/invented game from a specific group.
| Game | Mechanic | Players |
|---|---|---|
| Knock Rummy | Rummy + "knock" to end round | 2-4 |
| Nerts / Pounce | Real-time multiplayer solitaire | 2-6 |
| Knockout Whist | Trick-taking, eliminate players | 3-7 |
| Chicago / Rotation | Poker variant, "knock" to draw | 2-7 |
| Knucklebones | Dice/jacks game (not cards) | 1+ |
With a few details, I can either identify it or help you reconstruct the rules!