"Fame" varies by region, generation, platform, and culture. A game ubiquitous in Seoul may be unknown in São Paulo. Instead of a false #1, here are the leaders across measurable categories:
If forced to pick one with the broadest combination of sales, recognition, longevity, and cultural footprint across all demographics: Chess or Football. Among video games: Minecraft or Tetris.
But the better question is: Famous to whom, where, and when? The answer changes every generation.