The classic deduction game Clue (Cluedo) has exactly 324 possible case solutions.
Each solution combines one suspect, one weapon, and one room:
6 × 6 × 9 = 324 unique combinations.
At game start, one random combination is placed in the envelope. The remaining 18 cards are dealt to players. Through suggestions and deductions, players eliminate possibilities until only the envelope's trio remains.
324 is the canonical number for standard Clue — enough for high replayability, few enough for human deduction.