HT Games
There are many Simpsons games. To answer, I need to know which specific title you mean. Major releases by platform:
| Game | Platforms |
|---|---|
| The Simpsons: Hit & Run (2003) | PS2, Xbox, GameCube, PC |
| The Simpsons Game (2007) | PS2, PS3, Xbox 360, Wii, NDS, PSP |
| The Simpsons: Tapped Out (2012) | iOS, Android (mobile only) |
| The Simpsons Arcade (1991/2012) | Arcade, PS3, Xbox 360 (digital) |
| Bart vs. the Space Mutants (1991) | NES, SMS, Game Gear, Amiga, C64 |
Tell me the exact game title (or year, platform you own) and I'll confirm compatibility.