Guitar Controllers for Nintendo Wii: Only the Wii Guitar Works

Real guitars cannot connect to the Nintendo Wii. The console lacks the necessary audio/MIDI interfaces, drivers, and software support. For guitar-based games (Guitar Hero, Rock Band), you must use the Wii Guitar Controller—a plastic, guitar-shaped peripheral with a Wii Remote dock.

Only the official (or licensed third-party) Wii Guitar Controller works. No adapters, interfaces, or workarounds exist for real instruments on the original Wii hardware.

If you want to play with a real guitar, look at PC/Mac options like Rocksmith (requires Real Tone Cable) or Clone Hero (supports various controllers). On Wii, it's plastic or nothing.