Is PSP Compatible with Nintendo Games? No—Completely Incompatible Platforms

No. The PSP (PlayStation Portable) and Nintendo systems (DS, 3DS, Switch, Game Boy, etc.) are completely incompatible platforms.

Hardware Barriers

Aspect	PSP	Nintendo (DS/3DS/Switch)
CPU Architecture	MIPS (Allegrex) / ARM (Media Engine)	ARM (ARM9/ARM11/Cortex-A57)
Media	UMD (optical), Memory Stick, Digital	Game Card (cartridge), SD/microSD, Digital
OS / SDK	Proprietary (PSP OS)	Proprietary (Nintendo SDK)
Binary Format	ELF / PRX / PBP	NRO / NCA / CIAs / .nds / .3ds

PSP → Nintendo: No DS/3DS emulator runs on PSP (insufficient RAM/CPU). GBA emulators exist (gpSP-J, TempGBA) — play Game Boy Advance games only.
Nintendo → PSP: No PSP emulator runs on DS/3DS (insufficient power). Switch can run PPSSPP (homebrew) for PSP games.

To play Nintendo games, buy Nintendo hardware. To play PSP games, buy PSP (or Vita/PS TV/PC via PPSSPP).

PSP Games