No, a standard PC optical drive cannot read or play PS2 game discs.
Why Not?
Disc format: PS2 uses a proprietary DVD-ROM format with a unique file system and encryption.
Copy protection: Discs include wobble-groove and other anti-piracy measures only the PS2 laser firmware understands.
Hardware: The PS2's custom CPU (Emotion Engine) and GPU (Graphics Synthesizer) are not present in PCs.
Legal Alternatives
Emulation (PCSX2): The leading open-source PS2 emulator for Windows/Linux/macOS. Requires a decent CPU (AVX2 recommended) and your own legally dumped BIOS and game ISOs.
PlayStation Plus Premium: Streams a curated library of PS2 classics to PC (subscription required, region-dependent).
Original hardware: Buy a PS2 console (fat or slim) and component/HDMI upscaler for the best native experience.
Reminder: Downloading BIOS files or ISOs for games you don't own is copyright infringement. Dump your own discs/BIOS to stay legal.
