The original Diablo II (2000) has no native macOS version. But you have several excellent options today, from a native remaster to virtualization.
The 2021 remaster runs natively on macOS (Apple Silicon and Intel). It includes updated 3D rendering, 4K support, quality-of-life improvements (shared stash, auto-gold pickup), and cross-progression with PC/console. Buy on Battle.net (~$40). This is the easiest, most stable, feature-complete way to play on Mac.
Stream Diablo II: Resurrected via Xbox Cloud Gaming (with Game Pass Ultimate) or GeForce Now in a browser. Requires stable internet. No local storage or GPU needed.
Recommendation: Diablo II: Resurrected native macOS is the clear winner for 95% of players. Use VM/Wine only if you specifically want the 2000 original (mods, PlugY, nostalgia).