The PS2's two front USB 1.1 ports (480 Mbps theoretical, ~1.5 MB/s real) support specific peripherals:
USB 1.1 is too slow for game streaming (1.5 MB/s vs. DVD 10 MB/s / HDD 40+ MB/s). USB gaming = long loads, stuttering, crashes.
For legitimate use: Keyboard for FFXI/EQOA, EyeToy, Headset. For homebrew: Internal HDD (Fat) or SMB (Slim) via OPL.