Can You Use a PlayStation Guitar Controller on Xbox 360? No – Different Connectors & Protocols

No. They use physically different connectors and proprietary protocols.

Feature	PlayStation Guitar (GH/RB)	Xbox 360 Guitar (GH/RB)
Connector	USB-A (dongle or wired)	5-pin DIN (proprietary) or Wireless (2.4 GHz Microsoft protocol)
Protocol	HID / Sony proprietary	Microsoft proprietary (Xbox 360 accessory protocol)
Security	None (PS3) / VID/PID (PS2)	Signed firmware / challenge-response

No Adapters Exist

No commercial or DIY adapter translates between these protocols. The Xbox 360 accessory port is encrypted and authenticated.

Buy an Xbox 360 guitar (wired PDP, wireless Gibson/RedOctane).
Use a PC: Both PS3 (USB) and Xbox 360 (wired USB or wireless via Microsoft Gaming Receiver) guitars work on PC with Clone Hero, Phase Shift, etc.

Xbox 360

Xbox 360