Connecting Guitar Hero Controllers to Xbox 360: Compatibility Guide
Depends on the controller version:
Xbox 360 Guitar Hero Controller (Wireless): Press Sync Button on console (front, near memory slots) → Press Sync Button on guitar (back, near battery) → Ring of Light locks to quadrant. Uses standard Xbox 360 2.4GHz protocol. Works natively.
Xbox 360 Guitar Hero Controller (Wired): Plug USB into front/back port. Works natively.
PlayStation 2/3 / Wii / PC USB Guitar:Will not work directly. Different protocols (PS2 proprietary, Wii Bluetooth, PC HID).