Burning a PC DVD game to a blank disc and expecting it to play simply doesn't work. Retail PC DVDs contain an installer (setup.exe, .msi, data.cab) that installs to your hard drive—the disc isn't bootable or runnable directly. Copy protection (SecuROM, SafeDisc, StarForce, Tages, Denuvo) verifies physical disc signatures like wobble grooves, ATIP, bad sectors, or twin sectors that consumer burners (DVD-R/+R) cannot replicate. The game executable also checks for the original disc signature in the drive, failing on burned copies. Multi-disc installs spanning .cab files across discs break paths when burned as a single ISO.
Bottom Line: Don't burn. Mount the ISO via virtual drive or rebuy DRM-free on GOG.