There is no single "hardest KenKen," but difficulty is determined by a combination of structural factors. Puzzle designers (and the KenKen app/books) use these levers to create "Expert" / "Master" / "Insane" tiers.
9×9 grid, all multiplication/division cages, 5–7 cell cages, prime-heavy target numbers (e.g., 5040 = 7!), no-op cages, minimal symmetry. Solvable only by computer or elite humans.
Remember: "Hardest" is subjective. A 6×6 with clever logic can be harder than a brute-force 9×9.