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Infamous on Nintendo DS? No—It's a PlayStation Exclusive (PS3/PS4)

There is no Infamous game on Nintendo DS. The Infamous series (developer: Sucker Punch Productions, publisher: Sony Interactive Entertainment) is a PlayStation exclusive franchise.

Infamous Series Platforms

Game	Platform(s)	Year
Infamous	PS3	2009
Infamous 2	PS3	2011
Infamous: Festival of Blood	PS3 (DLC/Standalone)	2011
Infamous Second Son	PS4	2014
Infamous First Light	PS4 (DLC/Standalone)	2014

Why No DS Version?

Hardware Gap: Infamous requires open-world streaming, particle physics, shader-based powers. DS (4 MB RAM, 67 MHz ARM9) cannot approximate.
Sony First-Party: Sucker Punch owned by Sony since 2011 (second-party before). Never multiplatform.
Timeline: DS peak 2004–2010. Infamous launched 2009 — by then, Sony focused on PSP/PS3.

Similar Games on DS (Open World / Superpowers)

The World Ends With You: Shibuya, psychic pins, action RPG. Masterpiece.
Grand Theft Auto: Chinatown Wars: Top-down open world, drug economy, missions.
Spider-Man: Web of Shadows (DS): 2D Metroidvania, web-swinging, choices.
Assassin's Creed: Altaïr's Chronicles: 2.5D platformer, parkour.
C.O.P. The Recruit: Open-world driving/shooting. Ambitious but janky.

If You Want Infamous Portable

PS Vita: Remote Play Infamous Second Son from PS4 (local network / internet).
PSP: No Infamous. Resistance: Retribution, God of War: Chains of Olympus for Sony action.
Steam Deck / ROG Ally / Legion Go: Play Infamous via PS Now (streaming) or future PC port (rumored).

Infamous = PlayStation only. DS has great alternatives—but not Cole MacGrath.

Nintendo DS