Can Nintendogs Have Puppies? No—But These Games Let You Breed Dogs

The Nintendogs series (DS, 3DS) does not include breeding or pregnancy mechanics. Gameplay focuses on training, care, competitions, and social features (Bark Mode/StreetPass for meet-ups—but no offspring).

Games With Actual Dog Breeding

• The Sims 2: Pets / The Sims 3: Pets / The Sims 4: Cats & Dogs – Full genetics, litters, trait inheritance
• Harvest Moon / Story of Seasons – Farm dogs can have puppies
• Dragon Quest Monsters, Pokémon – Breeding mechanics for egg moves/IVs (monster/pokémon breeding)
• Dogz (PC/GBA/DS Ubisoft series) – Some entries allow breeding

Best Modern Option

The Sims 4: Cats & Dogs offers the most polished virtual pet breeding experience: Create-a-Pet with breed presets (including Great Dane), genetic inheritance, pregnancy stages, and litter management—all in a modern, accessible package.

If you want a virtual pet that reproduces, this is your best bet. Nintendogs was designed as a pure care/training simulator without generational mechanics.