Can PSP Games Run on PlayStation 2?

No. PSP and PS2 are fundamentally incompatible platforms:

• Media: PSP uses UMD (Universal Media Disc); PS2 uses DVD-ROM.
• Architecture: PSP (MIPS R4000-based) vs. PS2 (Emotion Engine MIPS III + VUs).
• OS/Executable Format: PSP runs .PBP/.ISO; PS2 runs .ELF on DVD.

Ports Exist: Some PSP titles received native PS2 ports (e.g., Grand Theft Auto: Liberty City Stories & Vice City Stories were ported to PS2). These are separate, recompiled versions, not the PSP UMD running on PS2.