PS2 Games Cannot Work on PSP — Different Architectures, No Native Support

No. The PS2 and PSP have fundamentally different architectures:

• Hardware: PS2 is a home console with a custom Emotion Engine CPU; PSP is a handheld with a MIPS-based processor.
• Media: PS2 uses DVD discs; PSP uses UMD (Universal Media Disc) or Memory Stick.
• Software: PS2 games are compiled for PS2 hardware and OS; they cannot run natively on PSP.

Emulation (Unofficial & Limited)

Some homebrew emulators attempt to run PS2 games on PSP, but performance is extremely poor—most titles are unplayable due to the PSP's limited RAM and GPU. This also requires custom firmware, which voids warranties and carries legal/ethical concerns regarding game ownership.

Best Option: Play PS2 games on a PS2, a backward-compatible PS3, or via official ports/remasters on modern platforms.