Absolutely not. The hardware architectures are fundamentally incompatible.
| Specification | PlayStation 2 | PlayStation 3 |
|---|---|---|
| CPU | Emotion Engine (MIPS III, 294–299 MHz) + VU0/VU1 | Cell Broadband Engine (PPE + 7 SPEs, 3.2 GHz) |
| GPU | Graphics Synthesizer (147 MHz, 4 MB eDRAM) | RSX Reality Synthesizer (550 MHz, 256 MB GDDR3) |
| RAM | 32 MB RDRAM (System) + 4 MB VRAM | 256 MB XDR + 256 MB GDDR3 |
| Disc Media | DVD-ROM (4.7/8.5 GB), CD | Blu-ray (25/50 GB), DVD, CD |
| Architecture | Custom MIPS, Fixed Function Pipeline | PowerPC-based, Programmable Shaders |
The PS2 lacks the CPU instruction set, GPU shader model, memory bandwidth, and Blu-ray laser to read or execute PS3 code. It is physically impossible.
Best Way Today: Play PS2 games on PC via PCSX2 (near-perfect emulation, 4K, widescreen patches, texture filtering) or on PS4/PS5 via PS2 Classics ports (trophy support).