No. The PlayStation 3 cannot play Nintendo GameCube games. The hardware, media, and software architectures are fundamentally incompatible.
| Component | PS3 | GameCube |
|---|---|---|
| CPU | Cell Broadband Engine (1 PPE + 7 SPEs, PowerPC-based) | Gekko (PowerPC 750CXe, single core) |
| GPU | RSX (Nvidia G70 derivative) | Flipper (ATI/ArtX, fixed-function + TEV) |
| RAM | 256 MB XDR + 256 MB GDDR3 (Split) | 24 MB 1T-SRAM + 16 MB DRAM (Unified) |
| Media | Slot-loading 12cm DVD/BD | Top-loading 8cm miniDVD (1.4 GB) |
| OS/API | GameOS / Hypervisor | Bare-metal proprietary |
No translation layer exists. Instruction sets differ; GPU register maps differ; media physically incompatible.
PS3 is a dead end for GameCube. Get a Wii (cheap, native BC) or use Dolphin.