Can You Play PSP Games on PS2? No — Incompatible Hardware & Media

No. PSP games cannot be played on PlayStation 2.

Why

• Different hardware: PSP (MIPS CPU, custom GPU) vs. PS2 (Emotion Engine, GS)
• Different media: PSP uses UMD (Universal Media Disc); PS2 uses DVD-ROM
• Different software architecture: Binaries, libraries, APIs are incompatible

Note

Some PSP games were ported to PS2 (e.g., God of War: Chains of Olympus → no, that stayed PSP; Persona 3 Portable → PS2 got Persona 3 FES instead). Ports are separate releases, not the same disc/UMD.