Are There Left-Handed Video Game Characters? (Yes — Notable Examples)
Yes. Several prominent characters are canonically left-handed or wield weapons left-handed:
Confirmed Left-Handed
Link (The Legend of Zelda) — Left-handed in every game until Twilight Princess (Wii) (mirrored for right-handed Wii Remote). Skyward Sword (Wii) forces right; Breath of the Wild / TotK — right-handed (design choice). Canonically lefty in lore/art.
Geralt of Rivia (The Witcher) — Wields steel sword in left hand, silver in right (reverse of traditional). Combat animations built around left-hand dominance.