Yes, you can use RPG Maker sprites in a comic — but check the license first.
License Tiers
RTP (Run-Time Package) Assets: Included with RPG Maker (VX Ace, MV, MZ, etc.). Allowed: Free/commercial games made in RPG Maker. Gray Area: Use outside engine (comics, other engines) — Degica/Enterbrain historically tolerates but doesn't explicitly permit. Credit "RPG Maker RTP."
DLC Packs (Fantasy, Modern, Sci-Fi, etc.): Same as RTP — typically restricted to RPG Maker projects.
Community "Free for Commercial Use" Packs: Sites like itch.io, RPG Maker Web Forums, OpenGameArt.org — many artists release edits/originals with CC-BY, CC0, or custom "free for any project" licenses. These are safe for comics.
Commissioned / Original Art: Safest — you own rights.
Best Practices for Comics
Read the License: Every pack has a `README` / `LICENSE.txt`. Search "commercial use," "derivative works," "outside RPG Maker."
Attribute: Credit artist/pack in comic credits (e.g., "Sprites by Avery (RPG Maker VX Ace RTP)").
Edit for Fit: Recolor, resize, add expressions, combine parts — makes it yours and avoids "asset flip" look.
Resolution: RPG Maker sprites are small (32×32 or 48×48). Upscale with nearest-neighbor (pixel-perfect) or use AI upscaler (Anime4K, ESRGAN) for print.
Alternatives If License Unclear
OpenGameArt.org — Filter "CC0" or "CC-BY" + "sprites."
Itch.io "Assets" tag — Many free pixel art packs.
Kenney.nl — High-quality public domain game assets.
When in doubt, ask the artist or use explicitly licensed assets.