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Oblivion (Xbox 360): Vampirism Cure Is Permanent—You Cannot Become a Vampire Again

No. In The Elder Scrolls IV: Oblivion (Xbox 360), the vampirism cure is permanent. You cannot contract it again through normal gameplay.

Why

  • The "Cure Disease" spell/potion/altar sets a permanent flag: PCVampire = 0 + VampirismCured = 1.
  • Game scripts block re-infection: vampire NPC bites apply "Porphyric Hemophilia" disease, but the cured flag prevents transition to full vampirism.
  • No console commands on Xbox 360 to reset flags.

Vampire-Like Alternatives (No Re-infection)

Ability / ItemSourceEffect
Vampiric Drain spellMysticism / RestorationAbsorb Health + Magicka on touch. Scales with skill.
Vampiric Touch (Power)Dark Brotherhood rankTouch: Absorb 10 Health + 10 Magicka. 1/day.
Shrouded Armor (set bonus)DB questlineChance on hit: Absorb Health.
Blood of the Ancients (mod)PC only (OBSE)Restores full vampire mechanics.

PC Mods (Not Xbox 360)

  • Better Vampires, Vampiric Thirst, Sacrosanct – Overhaul vampirism, allow re-infection, feeding mechanics, powers.
  • Require Oblivion Script Extender (OBSE) – PC only.

Summary

  • Xbox 360: One-way trip. Cure = never vampire again.
  • Want vampire playthrough? Don't cure. Or start new character.
  • PC: Mods restore full vampire lifecycle.

Choose carefully when the "Cure Vampirism" quest appears.

Xbox 360
Xbox 360

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