Using Guitar Hero 2 PS2 Guitar on Rock Band Xbox 360: Not Possible

You cannot use a Guitar Hero 2 PS2 guitar on Rock Band for Xbox 360.

Reasons:

• Platform Incompatibility: PS2 and Xbox 360 use different hardware/software ecosystems.
• Different Guitar Designs: Internal components, button layouts, and communication protocols differ.
• Proprietary Technology: Both franchises use proprietary controller protocols.

Solutions:

• Buy a Rock Band Guitar for Xbox 360: Most reliable option.
• Third-Party Adapters: Rare, unreliable, and largely unavailable now.

You need an Xbox 360-compatible Rock Band guitar to play on that console.