SanDisk Cruzer Glide USB Works on Xbox 360 — Here's How to Set It Up
Yes, you can. Since a 2011 dashboard update, the Xbox 360 supports standard USB flash drives (like the SanDisk Cruzer Glide) for game saves, profiles, and game installs.
How to Set It Up
Plug the drive into a front USB port.
Go to Settings > System > Storage.
Select the USB device and choose Configure Now (formats it for Xbox 360).
Supports up to 2 TB (previously 32 GB limit).
Warning: Formatting erases all existing data on the drive.