Can You Save With Cheats Enabled in Red Dead Redemption? No—Permanently Disables Saving

No. Activating any cheat code in Red Dead Redemption (Xbox 360, PS3, or backward compatible) permanently disables saving for that session.

Details

• Cheats are entered via the pause menu → "Cheats."
• Once a cheat is activated, the "Save" option grays out and auto-saves stop.
• You cannot re-enable saving by turning the cheat off; you must reload a pre-cheat save or start a new game.
• Achievements/Trophies are also disabled for that save file.

Why Rockstar Designed It This Way

To preserve the integrity of the progression system and leaderboards. Cheats are for sandbox fun after you've finished the story, not for skipping challenges.

Pro Tip

Keep a separate "clean" save file before experimenting with cheats.