DS Lite Cannot Play Game Boy Color Games — Here's Why & What Works
The Nintendo DS Lite cannot play Game Boy Color cartridges.
Hardware Reasons
Slot-1 (DS Card) only accepts DS cards.
Slot-2 (GBA) accepts GBA carts + original Game Boy / Game Boy Color carts electrically, but the DS Lite lacks the Z80 co-processor and 5V regulator required to boot GB/GBC mode. The GBA slot on DS/DS Lite is wired for GBA voltage/signals only.
Original DS (Phat) also cannot play GB/GBC — same missing hardware.
What Works
Game Boy Advance / SP / Micro: Native GB/GBC hardware (switches CPU mode via cartridge shape detect).
Game Boy Color / Pocket / Light: Native.
3DS / 2DS / New 3DS: Native GB/GBC via Virtual Console (eShop) or Open_AGB_Firm (CFW) for cartridge play via Slot-2 adapter (not native slot).
Flashcart (EZ-Flash Jr / EverDrive GB) on GBA/SP/Micro/DS/3DS: Load ROMs from microSD.