Officially: No. Nintendo games are engineered exclusively for Nintendo hardware. Cartridges/discs use proprietary formats; software is compiled for Nintendo's custom OS and instruction sets; DRM (encryption, signature checks) prevents execution elsewhere.
If you want to play BotW, TotK, Metroid Dread, Pokémon Scarlet/Violet — buy a Switch (or Switch 2). For legacy titles, a used 3DS/Wii U/Wii/GameCube + original carts/discs is the most authentic, legal route. Emulation on PC/Steam Deck is the best enhanced experience for games you already own.