No. Killzone 3 supports both the PlayStation Move and the standard DualShock 3 controller. Move is entirely optional—an alternative control scheme for motion-based aiming. The full campaign, multiplayer, and all modes are playable with a traditional gamepad.
Play with DualShock 3. It's more comfortable for long sessions, doesn't require camera calibration, and the aiming is tuned for analog sticks. Try Move if you're curious—it's a novelty, not a necessity.