Chrono Cross is notoriously finicky on POPS (PS1 emulator for PSP). Common fixes for 5.00 M33-3 + POPSLoader:
Chrono Cross Disc 1.iso / Chrono Cross Disc 2.iso in same folder. Enable "Disc Swap" in POPSLoader settings.defrag X: /U).vsh.txt / game.txt, comment out all plugins except POPSLoader.POPS on PSP is legacy. Adrenaline or PC is the modern way.