Can You Use Rock Band Wii Guitars for Guitar Hero? No — Incompatible

No, Rock Band Wii guitars do not work natively with Guitar Hero on Wii.

Why

• Different communication protocols.
• Different button layouts.
• No official cross-support.

Workarounds (Unreliable)

• Third-party adapters: Exist but often buggy; compatibility varies by game version.
• Hardware modding: Complex, risky, not for beginners.

Best option: Use official Guitar Hero controllers. Note: Wii Guitar Hero games are long out of production — consider PC (Clone Hero) or newer consoles for active communities.