No. Saving on one Wii game disc does not affect another copy of the same game. Save data lives on the Wii's internal NAND flash memory (512 MB) or SD card—not on the game disc. Discs are read-only.
RSPE01 for Super Mario Galaxy NTSC-U)./title/00010000/52535045/ (hex for RSPE) on NAND.RSPE01 → they read/write the same save folder.RMCE01. Separate folder. Zero overlap.RSPE01) vs PAL (RSPP01) = different Title IDs = separate saves./saves/ on USB). Still per-Title-ID.Disc = read-only key. Console = save vault. Swap discs freely. Your progress follows the console, not the plastic.