Yes, most Rock Band and Guitar Hero instruments work on Xbox 360, but with important caveats.
| Instrument | Works with Rock Band | Works with Guitar Hero |
|---|---|---|
| Rock Band Guitars/Drums | Yes (all titles) | Mostly (GH3, GH:WT, GH5, BH, WoR) |
| Guitar Hero Guitars (GH3+) | Mostly (RB1, RB2, RB3, Lego RB, Green Day RB) | Yes (all GH titles) |
| Guitar Hero II / III Guitar (Xbox 360 version) | No (GHII) / Yes (GHIII+) | Yes |
| Guitar Hero World Tour / Band Hero Drums | Yes (5-lane cymbals map to 4 pads) | Yes |
| Rock Band Keyboards / Pro Instruments | Yes (RB3 only) | No |
Best Practice: Check the specific game's manual or Harmonix's compatibility chart before buying used gear.