Short answer: No. The Guitar Hero III (Les Paul) wireless controller does not work with the original Guitar Hero on PlayStation 2.
| Game | Controller Protocol | Dongle |
|---|---|---|
| Guitar Hero I (2005) | Wired (PS2 controller port) or RedOctane Wireless (2.4 GHz proprietary) | Specific to GH1/GH2 dongle |
| Guitar Hero II (2006) | Same as GH1 | Same dongle |
| Guitar Hero III (2007) | New wireless protocol (different chipset) | New dongle (black, smaller) |
| GH1/2 Dongle | GH3 Dongle | GHWT/5/6 Dongle | |
|---|---|---|---|
| GH1/2 Guitar (Wired) | ✅ | ❌ | ❌ |
| GH1/2 Wireless | ✅ | ❌ | ❌ |
| GH3 Les Paul | ❌ | ✅ | ✅ (GHWT+) |
| GHWT/5/6 Guitar | ❌ | ✅ | ✅ |
Solution: Pick up a GH1/2 wireless guitar with its dongle (often ~$30 on eBay) or use a wired GH1/2 controller. The GH3 guitar works perfectly on GH3, World Tour, 5, Warriors of Rock, and Band Hero.