No, not natively. The Guitar Hero III: Legends of Rock Les Paul controller (PS3) **will not work** with Rock Band 1, 2, 3, Beatles, Green Day, Lego Rock Band on PlayStation 3.
| Method | Pros | Cons |
|---|---|---|
| Rock Band 3 Pro Guitar (Mad Catz/Fender) | Works natively in GH3, GH:WT, GH5, Warriors of Rock, Band Hero AND all Rock Band titles. | Expensive ($150+ used); 102-button layout steep learning curve. |
| Third-Party Adapter (e.g., "GH to RB" dongle) | Lets GH3 guitar act as RB guitar. | Rare, discontinued, often laggy, breaks whammy/tilt calibration. PS3 drivers may block non-licensed HID devices. |
| CronusMAX / Titan Two + Script | Translates GH3 input → RB output via PC/Console. | $60+ device; complex setup; input lag; TOS risk online. |
Buy a **Rock Band 3 Fender Mustang Pro Guitar (PS3)** or **Mad Catz Rock Band 3 Wireless Fender Stratocaster**. They are the only controllers guaranteed to work across *both* franchises on PS3. Standard RB1/2 guitars work for all Rock Band games but not Guitar Hero (except GH: World Tour+ which added RB support).
TL;DR: GH3 guitar = e-waste for Rock Band. Sell it, buy a RB3 Strat or Mustang.