Are Madden NFL 11 or 12 Compatible with PS Vita?

Unfortunately, neither Madden NFL 11 nor Madden NFL 12 are compatible with the PlayStation Vita.

The PlayStation Vita is not backwards compatible with PSP games. This means games designed for the PSP will not work on the Vita.

If you're looking for Madden NFL games on the Vita, you'll need to check for titles specifically designed for the platform.