Not natively. Xbox 360 games are compiled for its custom PowerPC architecture and OS—they won't run on x86 Windows/Linux/macOS.
Workarounds (With Caveats)
Xbox Cloud Gaming (Game Pass Ultimate): Stream select Xbox 360/One/Series titles to PC via browser/app. Requires subscription + good internet.
Emulation (Xenia, RPCS3 for PS3): Xenia can run some Xbox 360 games on high-end PCs. Legal gray area: Requires owning game files; downloading ISOs is piracy. Setup is complex.
Best Legal Path
Xbox Game Pass Ultimate cloud streaming for supported titles.
Purchase PC ports/remasters (many 360 games have them).
Avoid shady "Xbox 360 emulator" downloads—they're often malware.