Can Resident Evil 5 PC Play Cross-Platform with Xbox 360? No

No. Resident Evil 5 does not support cross-platform play between PC (Steam/GFWL) and Xbox 360.

Why

• Separate online ecosystems: Games for Windows Live (PC) vs. Xbox Live (360).
• No cross-play implementation in original release (2009) or Gold Edition.
• Capcom has not added cross-play via patches.

Co-op Options

• PC + PC: Steam/GFWL friends (GFWL deprecated; Steamworks version works).
• Xbox 360 + Xbox 360: Xbox Live Gold required (still functional).
• PS3 + PS3: PSN (still functional).
• Modern Ports: RE5 on PS4/PS5/Xbox One/Series/Steam (2019) – still no cross-play between platforms.

To play together, both must be on the same platform.